Use(s) or Purpose(s)
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- Used for preventing cardiovascular disease, varicose veins, hemorrhoids, atherosclerosis, hypertension, peripheral vascular disease, edema associated with injury or surgery, and myocardial or cerebral infarction. Used and as a mild laxative for constipation. Grape “fasts” have been used for “detoxification.”
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- Used for diabetes complications such as neuropathy or retinopathy, improving wound healing, preventing dental caries, cancer prevention, age-related macular degeneration (ARMD), poor night vision, liver cirrhosis, allergic rhinitis, and prevention of collagen breakdown. Used orally for attention deficit-hyperactivity disorder (ADHD), chronic fatigue syndrome (CFS), diarrhea, heavy menstrual bleeding, uterine hemorrhage, and canker sores.
Risk Information
Caution(s) and Warning(s)
No statement is required.
Contraindication(s)
No statement is required.
Known Adverse Reaction(s)
Orally, grape seed extract is well tolerated. Headache, abdominal pain, sore throat, nausea, and cough have been reported with used of grape seed, but these effects occur at rates similar to placebo. Excessive consumption of grapes, dried grapes, raisins, or sultanas might cause diarrhea due to laxative effects. There is one report of an anaphylactic reaction to grape skin extract, which included urticaria and angioedema. Grape leaves have been reported to cause gastrointestinal discomfort, diarrhea, dyspepsia, dry mouth, and retching. Other adverse effects included infections, headache, and musculoskeletal disorders. One case of leg hematoma following a minor trauma was also reported in a person using grape leaf extract.