{"id":13912,"date":"2020-09-16T18:21:15","date_gmt":"2020-09-16T18:21:15","guid":{"rendered":"https:\/\/7f3f0783c8.nxcli.net\/?p=13912"},"modified":"2020-09-16T19:43:18","modified_gmt":"2020-09-16T19:43:18","slug":"etude-sur-lefficacite-de-bifilact","status":"publish","type":"post","link":"https:\/\/viragesante.com\/en\/etude-sur-lefficacite-de-bifilact\/","title":{"rendered":"\u00c9tude sur l’efficacit\u00e9 de Bifilact\u00ae"},"content":{"rendered":"

Impact des probiotiques sur la diarrh\u00e9e radio-induite chez les patients recevant des traitements de radioth\u00e9rapie<\/h2>\n

Les effets secondaires de type gastro-intestinaux sont fr\u00e9quents chez les patients soumis \u00e0 un traitement de radioth\u00e9rapie. On estime que plus de 70% des patients d\u00e9velopperont une inflammation aigu\u00eb\u2009(1).<\/p>\n

 <\/p>\n

\u00c9tude \u00e0 double insu, compar\u00e9e \u00e0 un placebo (229 patients)<\/h4>\n

Une \u00e9tude r\u00e9cente (\u20092012\u2009) men\u00e9e par l’\u00e9quipe de radio-oncologie du CHUQ<\/strong> a test\u00e9 l’efficacit\u00e9 du Bifilact\u00ae, un probiotique double souche (Bifidobacterium longum<\/em> BB536<\/strong> et Lactobacillus acidophilus<\/em> LAC 361<\/strong>) compar\u00e9 \u00e0 un placebo pour pr\u00e9venir ou retarder l’incidence des sympt\u00f4mes mod\u00e9r\u00e9s ou s\u00e9v\u00e8res de diarrh\u00e9e<\/strong> chez les patients recevant des traitements de radioth\u00e9rapie<\/strong>.<\/p>\n

 <\/p>\n

R\u00e9sultats<\/strong><\/h3>\n

Dosage et efficacit\u00e9<\/strong><\/h4>\n

L\u2019analyse statistique des 229 patients d\u00e9montre qu\u2019il n\u2019y a pas de diff\u00e9rence significative dans les trois groupes pour l\u2019incidence de diarrh\u00e9e mod\u00e9r\u00e9e \u00e0 s\u00e9v\u00e8re (p=0.1309) pendant le traitement de radioth\u00e9rapie. Toutefois la dose r\u00e9guli\u00e8re (standard) recommand\u00e9e par le fabricant (2,6 milliards UFC\/jour) a permis de diminuer de moiti\u00e9 l\u2019incidence de diarrh\u00e9e mod\u00e9r\u00e9e \u00e0 s\u00e9v\u00e8re \u00e0 la fin des traitements (\u00e0 60 jours) p=0.04<\/p>\n

<\/strong><\/p>\n

De plus, la prise d\u2019une dose plus \u00e9lev\u00e9e de Bifilact\u00ae (30 milliards UFC\/jour) n\u2019a pas apport\u00e9 de b\u00e9n\u00e9fices suppl\u00e9mentaire pour la pr\u00e9vention de la diarrh\u00e9e contredisant la croyance voulant que l\u2019ajout d\u2019une plus grande quantit\u00e9 de bact\u00e9ries assure une plus grande efficacit\u00e9.<\/p>\n

 <\/p>\n

Chez les patients subissant une chirurgie avant les traitements de radioth\u00e9rapie, le Bifilact\u00ae \u00e0 dose r\u00e9guli\u00e8re (2,6 milliards UFC\/jour) s\u2019est montr\u00e9 efficace pour r\u00e9duire l\u2019incidence de diarrh\u00e9e tout grade confondu (grade 0 \u00e0 4) (p=0.05) et de fa\u00e7on plus marqu\u00e9 la diarrh\u00e9e tr\u00e8s s\u00e9v\u00e8re (grade 4) (p=0,0329)<\/p>\n

 <\/p>\n

En r\u00e9sum\u00e9, la dose standard (2,6 milliards UFC\/jour) de Bifilact\u00ae est la dose \u00e0 privil\u00e9gier pour une meilleure efficacit\u00e9 et contribue \u00e0 pr\u00e9venir la diarrh\u00e9e chez cette population.<\/strong><\/p>\n

 <\/p>\n

S\u00e9curit\u00e9<\/strong><\/h4>\n

Une autre des conclusions importantes de l’\u00e9tude est que la prise de Bifilact\u00ae chez cette population s’est av\u00e9r\u00e9e s\u00e9curitaire et tr\u00e8s bien tol\u00e9r\u00e9e.<\/p>\n

 <\/p>\n

Recommandations du fabricant<\/strong><\/h4>\n

Pour des r\u00e9sultats optimaux, il est pr\u00e9f\u00e9rable de d\u00e9buter la prise du Bifilact\u00ae le plus t\u00f4t possible afin de pr\u00e9parer la flore intestinale et ainsi, favoriser de meilleurs r\u00e9sultats.<\/p>\n

Cliquez ici pour votre les r\u00e9sultats complets de l’\u00e9tude<\/a><\/p>\n

 <\/p>\n

Sources
\n(1) Resbeut M, Marteau P, Cowen D et al. A randomized double blind placebo controlled multicenter study\u00a0of mesalazine for the prevention of acute radiation enteritis. Radiotherapy oncology 1997; 44: 59-63.<\/h6>\n","protected":false},"excerpt":{"rendered":"

Impact des probiotiques sur la diarrh\u00e9e radio-induite chez les patients recevant des traitements de radioth\u00e9rapie Les effets secondaires de type gastro-intestinaux sont fr\u00e9quents chez les patients soumis \u00e0 un traitement de radioth\u00e9rapie. On estime que plus de 70% des patients d\u00e9velopperont une inflammation aigu\u00eb\u2009(1).   \u00c9tude \u00e0 double insu, compar\u00e9e \u00e0 un placebo (229 patients) […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1057],"tags":[],"class_list":["post-13912","post","type-post","status-publish","format-standard","hentry","category-apprendre"],"acf":[],"yoast_head":"\n\u00c9tude sur l'efficacit\u00e9 de Bifilact\u00ae – Virage Sant\u00e9 inc.<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/viragesante.com\/en\/etude-sur-lefficacite-de-bifilact\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c9tude sur l'efficacit\u00e9 de Bifilact\u00ae – Virage Sant\u00e9 inc.\" \/>\n<meta property=\"og:description\" content=\"Impact des probiotiques sur la diarrh\u00e9e radio-induite chez les patients recevant des traitements de radioth\u00e9rapie Les effets secondaires de type gastro-intestinaux sont fr\u00e9quents chez les patients soumis \u00e0 un traitement de radioth\u00e9rapie. 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